CBD and the Endocannabinoid System

Aug 3, 2020


After thousands of years of modern civilization, it’s fascinating to now know humans and animals alike have developed a system within our bodies to absorb and benefit from the use of cannabis and the active molecules, vitamins and nutrients found inside the plant. The two major players in this system are CBD and the Endocannabinoid System or as we would like to refer to it as the “ECS”. We also now know that CBD is just one of hundreds of cannabinoids found predominantly in the hemp plant. Over the last 20 years we have been able to research and develop systematic ways of tracking how our body uploads and processes these vital compounds throughout our bodies endocannabinoid system, and miraculously this all starts developing while we are still just infants growing in our mother’s womb!


The human body organically and naturally accommodates cannabinoids. Not only does the human body already make cannabinoids in small amounts, but they also occur throughout nature. Many plants have cannabinoids in them, not just cannabis hemp products. However, no other plants have them in as significant concentrations. Therefore, cannabinoids are not foreign substances our bodies aren’t designed to interact with or handle in large amounts. 

While CBD is a hemp plant-based cannabinoid (phyto-cannabinoid), our bodies also naturally produce cannabinoids, known as endo-cannabinoids. These endocannabinoids are part of our internal regulatory system called the “endocannabinoid system”. The endocannabinoid system is a biological system composed of endocannabinoids (cannabinoids naturally produced in the body), enzymes that synthesize and degrade cannabinoids, and cannabinoid receptors (primarily CB1 and CB2) found throughout the body and predominantly in the central and peripheral nervous systems.

In 1988 several scientists by the name of Allyn Howlett and Dr. William Devane at the St. Louis University School of Medicine found that the mammalian brain has receptors that indeed react to the cannabis plant. These receptors would eventually be deemed the most abundant neurotransmitter receptor in the human body. The Endocannabinoid System was only just recently discovered in 1992 by American Dr. William Devane and Dr. Lumin Hanus at the Hebrew University in Jerusalem. By studying the receptors they started to notice an interaction between the body and the system where these receptors were most abundantly found. By researching endocannabinoids and phytocannabinoids (body vs plant) they discovered a molecular signaling system, this system would eventually become known as the Endocannabinoid System



Just as we have a nervous system, respiratory system, and digestive system, we also have biological endocrine systems in our bodies. The endocrine system lies throughout the entire body in a series of glands. These glands control many different bodily functions — including but not limited to appetite, early growth, mood, and even sexual arousal. How do they do this? 

The endocrine system includes several components, including glands that regulate and produce hormones. These hormonal signals are the backbone of the endocrine system. They are how the endocrine system regulates itself and affects other systems in the body. Cannabinoids interact with the endocrine system through endocannabinoid receptors found in the entire body. These endocannabinoid receptors naturally occur in every mammal.

When we ingest large amounts of cannabinoids through hemp products, those cannabinoids merge with the endocannabinoid receptors in our bodies. Different cannabinoids affect people differently, depending on what endocannabinoid receptors they bind with and what tissues in the body those cannabinoids affect. 


The ECS system is a grouping of millions of receptors found throughout our body. Almost every organ of our body, including our skin and digestive tract, contain cannabinoid receptors but these are mostly found in the metabolic and nervous system. That’s why these receptors are primarily clustered together and found within the brain and central nervous system. The main purpose of the endocannabinoid system is to maintain homeostasis in the body. Homeostasis is our body’s way of regulating itself, it’s the internal balance, the ying and the yang, the ebb and flow that creates well being within ourselves. When one element becomes irregular and starts to alert us that we have an issue the endocannabinoid system jumps into overdrive to heal and create homeostasis and balance. The discovery of the endocannabinoid system has significantly advanced our understanding of health and disease. This naturally occurring system is responsible for the psychological and physical effects of the cannabis plant and its plethora cannabinoids that the plant inherently creates.


CBD oil is a non-psychoactive compound known for supporting overall wellness in humans and pets. CBD is being widely adopted by health enthusiasts around the globe for supporting cellular and molecular health. There are dozens of potential uses for the calming, focusing, and anti-inflammatory properties of organic full-spectrum CBD oil.   

It may help you maintain focus, promote a sense of calm and wellbeing, help your body’s natural ability to cope with stress (internal and external), recover from exercise-induced inflammation, support natural sleep cycles, and more. 


It comes down to the cannabinoids! When you look into the regulation of hemp versus marijuana and their history, the dividing line in the plants is all about cannabinoids. Before science could discern individual cannabinoids properly, lawmakers grouped the two plants. In recent years, we see a different regulatory system in the United States for hemp versus cannabis.

When considering the evolution of our bodies alongside the evolution of modern scientific technologies which help us to understand the importance of our natural endocannabinoid system, it is easy to see the benefits that our products provide. Proper Canna Naturals offers a variety of proven products that have been carefully developed to give our clients the maximum benefit in a controlled and perfectly measured way. Our formulas are the beautiful result of where pure science meets infinite nature. Visit our store to view our lines of Organic CBD tinctures, CBD topicals, and even CBD for pets. 

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Machelle Pike
Machelle Pike
18:11 20 Apr 22
My husband suffers from severe leg cramps. And not restless leg syndrome. I stoped to talk to Nikki at HOPE LIVES! I was tell her about my husbands horrible leg cramps. She asked me if he would use PROPER CANNA NATURALS? The one Ms. Nikki... suggested was a cream the name is Rocky Mountain chill. It’s a muscle gel. I brought it home he looked at it two or three days tried it and almost instantly it took his cramps away. He spent two days with no leg cramps whatsoever using that cream. We ran out of the sample I have ordered the big bottle and I can’t wait for it to get here. It was hard to imagine that some thing all natural could do what it did for him and he feel better and get sleep. Not only him but me because he was not up and down all night . Thank you Nikki for the recommendation. It’s the best. I will be looking into their other products. Sincerely Mikieread more
victoria odinet
victoria odinet
00:32 22 Mar 22
I love my monthly subscription to Proper Canna Naturals! The soft gels are part of my daily routine and the Rocky Mountain Chill feels good on a sore back. All of their products are made with Organic Colorado hemp and lots of love 🥰
Kileigh Lacey
Kileigh Lacey
17:36 15 Mar 22
I recently switched from another big box brand of CBD oil to Proper Canna. Within a few weeks I knew I had made a really great decision. My back use to hurt every day of the week. I have about 1-2 days a month after heavy exercise now that I will... get moderate pain. The customer service is stellar and the product ships to your home very quickly. I love the packaging and supporting a small business, all while feeling better inside and out. I do have to rave about the Rocky Mountain Chill Gel. It can kick a headache is 10 minutes! My husband and I both absolutely love it. I would highly recommend Proper Canna to anyoneread more
19:12 21 Feb 22
I stopped by this last Friday to try one of their CBD tinctures. Justin was AMAZING! We talked about the different products, and I ended up getting a bundle with the Rocky Mountain Freeze lotion. WOW I am very impressed with the quality of both.... Better then other brands I have tried! I recommend them to EVERYONE! Support Fort Collins local!read more
Shayna Perico
Shayna Perico
18:34 07 Jan 22
Tried a few of their products, and am really impressed at the quality! The dreamsicle tincture has really helped my sleep quality, which helps with my overall wellness. Met the owner, Dan, and such a stand up guy too! You can tell he is so... passionate about his products, and after trying them myself, I can see why! Would highly recommend Proper Canna Naturals!!read more
Mark Ariail
Mark Ariail
14:46 20 May 20
Amazing products! Amazing team! We appreciate your push to provide top-shelf products to help make our lives better. I have found a new home in Proper Canna Naturals! Thank you!
Derek Sidney
Derek Sidney
01:10 21 Mar 20
Love thees guys!! Would not shop anywhere else for a quality product. The mint is my favorite, and is now part of my nightly routine. I have also gifted the lotion / drops to my family and they all rave about it! Thanks Justin!
Griselda V
Griselda V
01:54 20 Mar 20
As an avid proponent of grass roots businesses that do it right. Not only have I tried most of the products Proper Canna produces but I have incorporated most of their products into my lifestyle, permanently. The muscle gel has come through for... me when my body aches after an intense yoga session or a long bike ride and if I’m cramping. The tincture supports my overall well being and keeps me focused and on point.read more
Mary-Louise Hayes
Mary-Louise Hayes
01:48 20 Mar 20
I use the cooling muscle gel and love it! As a triathlete there are days that every inch of my body aches and the cooling muscle gel helps tremendously with recovery. I’ve tried other products and this is by far the best!
Kevin Cottin
Kevin Cottin
01:14 20 Mar 20
Excellent quality and pricing. These people know what they are doing. I found a product that works great for me and I encourage you to give it a shot. I definitely will be placing more orders soon!
Dan Arensmeier
Dan Arensmeier
15:32 18 Mar 20
Best CBD / Hemp products in Northern Colorado. Certified organic, locally and sustainably sourced, manufactured and extracted. Their products have worked great for me and my dogs. I highly recommend them.
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